METTL16 and gastric cancer: found that overloaded copper ions in GC could accelerate the lactylation process of non-histone protein METTL16-K229 by promoting the interaction of lactyltransferases AARS1/AARS2 with METTL16(a key regulator of copper death in gastric cancer), in order to ultimately lead to the development of Cuproptosis (116).