Accordingly, the modification of TME by regulating the cancer immune environment has increasingly attracted the attention of researchers (203, 204).On the clinical outcome of bladder cancer and the score of the immune response experiment system, cuproptosis immune cell infiltration was found to be associated with bladder cancer prognosis, and high CD8+T cell infiltration predicted a positive prognosis (205). Here, CD8A is linked to urinary bladder carcinoma.