JAM3 and gastric cancer: It has been extensively demonstrated that factors associated with GC development, such as protocadherin 10 (PCDH10) (70), and junctional adhesion molecule 3 (JAM3) (71), lead to down-regulation of tumor suppressor genes (TSGs) through promoter hypermethylation in GC, are not infrequent in a wide range of GC types.