SIRT1 and Miyoshi myopathy: Finally, a VV modified to express Beclin-1 protein demonstrated the ability to induce significant autophagic cell death in MM cells by activating Sirtuin 1 (SIRT1) protein and promoting deacetylation and transfer of Microtubule-Associated Protein 1A/1B-light chain 3 (LC3) from the nucleus to the cytoplasm.