STAT1 and viral infectious disease: In addition, current methods of inhibitor, silencing, knockdown, and interference employing existing technologies are not specific, incomplete or unable to silence STAT1 gene expression, hence its critical to develop a pig STAT1-knockout cell line that can achieve complete silencing and long-term stability in vitro culture, laying a foundation for further research on the role of STAT1 in the pathogenesis of virus infection.