For example, a HIF-1α anti-sense lncRNA, HIFAL introduces the PKM2/PHD3 complex into the nucleus by binding to heterogeneous nuclear ribonucleoprotein F (hnRNPF) to enhance the production of hypoxia-inducible factor-1 (HIF-1) and promote breast cancer. The gene discussed is HIF1A; the disease is breast carcinoma.