For example, lncRNA ST3Gal6 antisense 1 (ST3Gal6-AS1) promotes metabolism of ceramide in osteosarcoma cells, then promoting the polarization of M2 macrophages, leading to higher level of IL-6 and IL-10 and causing immune escape in osteosarcoma (140, 141). This evidence concerns the gene ST3GAL6 and osteosarcoma.