In addition, it was found that in lung adenocarcinoma A549 cells, knocking out the INPP4B protein, which is involved in the PI3K-Akt-mTOR signaling pathway, utilizing CRISPR/Cas9 gene editing makes the cells more sensitive to ionizing radiation (IR), the PARP inhibitor olaparib and DNA homologous recombination repair is impaired. This evidence concerns the gene PIK3CA and lung adenocarcinoma.