In a study, it was shown that the drug resistance of human epidermoid carcinoma and NSCLC MDR cells was overcome by suppressing the activation of the PI3K 110α and 110β catalytic subunits using BAY-1082439 and CRISPR/Cas9 deletion of PI3Kca and PI3Kcb. The gene discussed is PIK3CD; the disease is squamous cell carcinoma.