In addition, it was found that in lung adenocarcinoma A549 cells, knocking out the INPP4B protein, which is involved in the PI3K-Akt-mTOR signaling pathway, utilizing CRISPR/Cas9 gene editing makes the cells more sensitive to ionizing radiation (IR), the PARP inhibitor olaparib and DNA homologous recombination repair is impaired. Here, INPP4B is linked to lung adenocarcinoma.