ESR1 and breast carcinoma: Ursolic acid is capable of inducing apoptosis in phenotypically distinct MCF-7 (ER+, PR+/−, HER2−), MDA-MB-231 (ER−, PR−, HER2−), and SK-BR-3 (ER−, PR−, HER2+) breast cancer cells via targeting the glycolytic pathway and autophagy (144).