BECN1 and cancer: Regarding the elevated expression of LC3 A/B, p62, and Beclin-1 in these cancer cells, they suggested that the significant antiproliferative activity of this compound was primarily due to its ability to induce autophagy (96). Another study has declared that celastrol and tamoxifen have synergistic anticancer effects by causing MCF-7 cells to undergo apoptosis and autophagy.