IL1B and Alzheimer disease: Since IL-1β is an important inflammatory cytokine that is overexpressed in AD brain (Mrak and Griffin, 2000), we treated cultured Nlrp3-knockout and wild-type primary pericytes with recombinant IL-1β at 0, 5, 10 and 50 ng/mL as we did in the human pericyte line (Quan et al., 2020).