APP and Alzheimer disease: In another study, the vascular volume detected by perfusion of cerebral arteries with [14C]-sucrose is reduced in 3 × Tg-AD, which overexpress human APPSwe, presenilin-1 (PS1M146V), and tau (tauP301L), but not in APP/PS1-transgenic mice, indicating the role of p-tau in vascular injury (Do et al., 2014).