PIEZO1 and Alzheimer disease: The expression of the Piezo1 gene and the production of the Piezo1 protein increase significantly with age, which explains the high prevalence of major neurological diseases in older individuals, such as the detection of Piezo1 expression in activated astrocytes surrounding amyloid plaques in patients with AD (Liu J. et al., 2021; Segel et al., 2019).