RYR2 and catecholaminergic polymorphic ventricular tachycardia: Dysfunctional gating of RyR2 due to stress modification or defective mutation of the channels will cause extra SR Ca2+ release in diastole that is termed as “SR Ca2+ leak”, which was first recognized in ventricular myocytes as an essential contributing factor to various ventricular pathological processes, such as heart failure and catecholaminergic polymorphic ventricular tachycardia (CPVT) (Huang et al.2021; Marks 2023; Miotto et al.2022; Mohamed et al.2018; Steinberg et al.2023).