In this study, we observed a novel regeneration-associated neuron type following CCI, namely, CIP (Atf3+) neurons, and identified their transcriptomic characteristics and intercellular communication.Atf3, a TF that was demonstrated to be necessary for nerve injury-induced transcriptional reprogramming, axonal regeneration and sensory recovery following injury [46,47], was significantly induced following CCI (Figure 4C). The gene discussed is ATF3; the disease is hereditary sensory and autonomic neuropathy.