According to the binary heatmap of regulon activity, we discovered that 6 TFs (Atf3,Bach1,Nfil3,Stat5a ,Sox9 andVax2) exhibited specific activation in CIP and regulated the significant DEGs of CIP, includingFgf3,Csf1,Tnfrsf12a,Igfbp3, andGpr151. The gene discussed is SOX9; the disease is hereditary sensory and autonomic neuropathy.