Regarding the periodontitis model of the beagle dog, Masson's staining showed a higher degree of bone mineralization in CS–CSn (pDNA‐BMP2)–GP group compared to CS–GP group, and ALP assay revealed ALP activity (an osteoblast‐differentiation marker) to be the highest among CS–CSn (pDNA‐BMP2)–GP compared to CS/GP and control groups, indicating the endogenous bone regeneration potential of pDNA‐BMP2 (Li, Ji, et al. 2017). Here, BMP2 is linked to periodontitis.