Evidenced by previous research in gastric cancer, pancreatic cancer, and hepatocellular carcinoma, we discern that TRIM50 predominantly performed as a tumor suppressor gene via dampening the output of epithelial–mesenchymal transition (EMT)-related pathway.25–27 However, the role of TRIM50 in breast cancer and its underlying molecular mechanism have not been reported yet and merits further dissection. The gene discussed is TRIM50; the disease is breast carcinoma.