As a new member of the TRIM family,25,36,37 TRIM50 was once documented as a ubiquitin ligase with proautophagic activity and a candidate tumor suppressor in hepatocellular carcinoma, ovarian cancer, and pancreatic cancer.26,27,38 TRIM50 could suppress the EMT event and tumorigenicity by K48-linked poly-ubiquitination of Snail protein in hepatocellular carcinoma and pancreatic cancer.26,27 Although the functions of TRIM50 in TNBC were not elucidated yet, these studies still provide the possibility for TRIM50 to be a tumor suppressor. This evidence concerns the gene TRAT1 and hepatocellular carcinoma.