In a cohort of 31 relapsed/refractory CLL patients, a CK was found in 13 out of 16 patients with TP53 mutations, while it was present in 4 out of 15 patients without TP53 mutations, highlighting the relation between TP53 mutation and genetic instability [430]. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.