TP53 and chronic myelogenous leukemia, BCR-ABL1 positive: Consistent with the proposal that alterations in the structure of the p53 gene might have a role in the evolution of the disease, Ahuja et al. observed deletions and rearrangements of p53 in 8 of 34 patients in BC and 1 of 4 patients in the AP, but in only 1 of 38 patients in the CP of CML [393].