TP53 and primary cutaneous T-cell non-Hodgkin lymphoma: In addition, p53 overexpression was observed in 10 out of 15 patients with CTCL who underwent large cell transformation (LCT), but no mutations were identified in 6 patients positive for p53 expression, highlighting that overexpression of p53 protein in LCT and disease progression of CTCL might be due to other mechanisms rather than TP53 mutation [632].