Mice were assessed at 30 weeks of age (pre-tumour) for body composition (Fig. 3A-C), glucose tolerance (Fig. 3D-E), fed and fasted insulin levels (Fig. 3F-H), and HOMA-IR (Fig. 3H); however, the only phenotype observed was a 2.8-fold increase in fed insulin levels in A1KO mice vs. WT mice (Fig. 3F, p < 0.05). The gene discussed is INS; the disease is neoplasm.