At 72 h post-infection, RV-A1-infected placebo-treated mice showed persistent expression of Cxcl2, Tnf- α and expression of Cxcl10, while ECSN6-treated mice showed persistent expression of Cxcl10 and no significant increase in the expression of Cxcl2 and Tnf-α compared to sham-infected and placebo-treated mice (Fig. 7A and E). The gene discussed is TNF; the disease is infection.