Co-culturing Epidermal Growth Factor Receptor (EGFR) CAR-T cells with glioblastoma cells transfected with sgRNA for CRISPR screening demonstrated that the IFN-γ-R signaling pathway confers greater resistance to CAR-T cell killing in glioblastoma and other solid tumors, but not in leukemia and lymphoma, indicating distinct effects between solid and hematologic malignancies [113]. The gene discussed is EGFR; the disease is glioblastoma.