IL2 and neoplasm: For instance, Freitas et al. isolated GD-2 CAR-T cells co-cultured with tumor cells based on cytotoxic cytokine expression (TNF and IL-2) and identified MED12 and CCNC, components of the mediator cell cycle protein-dependent kinase module, as targets that enhanced anti-tumor immunity through transcriptional and epigenetic changes [63].