KLK3 and posterior cortical atrophy: As shown in Fig. 1H, I, J in all PCa subjects, the values of AUC were 0.8904 (95% CI, 0.8311 to 0.9497) for exosomal PSM-E, 0.5295(0.3812 to 0.6779) for tPSA and 0.7189 (95% CI, 0.5890 to 0.8487) for f/t PSA.