AGER and myocardial ischemia: For instance, inhibition of mitsugumin 53 (MG53) E3 ligase activity mediated with MG53S255 phosphorylation [109], activation of PI3K/Akt pathway [110], down-regulation of histone 3 lysine 9 acetylation through histone deacetylase [111] and suppression of HMGB1-RAGE (receptor for advanced glycation end products) axis [112] are all reported to be associated with attenuation of myocardial ischemia reperfusion injury.