Subsequently, the adiponectin performs its diverse functions primarily via the intricate binding mechanisms it exhibits with the AdipoR1/R2 or CDH13 receptors, and aforementioned changes of the pathophysiological mechanisms, including oxidative stress, miRNA, transcription factors, apoptosis, autophagy, and cellular signaling mentioned above, crucially regulate cardiac metabolism, affecting myocardial I/R injury under diabetes. The gene discussed is ADIPOR1; the disease is diabetes mellitus.