Disruption of this equilibrium may lead to metabolic disturbances, insulin and leptin resistance coexist in diabetes, obesity and CVD due to both of them share the same signal transduction pathways such as protein tyrosine phosphatase 1B (PTP1B) and suppressor of cytokine signaling 3 (SOC3) [123, 124]. This evidence concerns the gene PTPN1 and obesity disorder.