A recent individual patient data (IPD) level meta-analysis not only confirmed an increased risk of HLH/HLH-like systemic illnesses among patients with homozygous and heterozygous HAVCR2 mutations, but also suggested an age-dependent tendency to develop HLH/HLH-like systemic illnesses in children and young adults with SPTCL rather than in elderly patients [7]. Here, HAVCR2 is linked to subcutaneous panniculitis-like T-cell lymphoma.