ENPP1 and Right ventricular hypertrophy: In the present study, we report a novel homozygous splice-site variant in ENPP1 (NG_008206.1(NM_006208.3):c.2230 + 5G > A), in a Pakistani patient diagnosed with severe valvular pulmonary stenosis (PS) and mild right ventricular hypertrophy (RVH).