IFNG and asthma: Inhaling irritants strongly contributes to the development of asthma through two main mechanisms: firstly, it induces the death of AECs (Oikonomou et al. 2021), and secondly, it triggers the activation of various inflammatory mediators such as interleukin-17 (IL-17) and interferon-gamma (IFN-γ) (Yang et al. 2021).