Mechanistically, H2O2 induced oxidative modification of the serpin peptidase inhibitor clade A member 3 (SERPINA3), blocking its ubiquitin-dependent degradation and enhancing its activity as a transcriptional activator of PI3Kδ and TERT. PI3Kδ inhibition is a potential treatment for HCC [24]. The gene discussed is SERPINA3; the disease is hepatocellular carcinoma.