Studies have shown that PI-3065, a small-molecule inhibitor of PI3K delta, can suppress survivin expression and directly induce apoptosis of HCC cells, cause mitochondrial toxicity, and inhibit the migration, colony formation, and epithelial to mesenchymal transition abilities of HCC cells, ultimately exerting anti-tumor effects in vivo and in vitro. The gene discussed is BIRC5; the disease is hepatocellular carcinoma.