In contrast to thyroid SMECE which is a distinct entity arising in the background of fibrosing Hashimoto thyroiditis and lacking MAML2 gene alterations, salivary SMEC is a rare variant of MEC characterized by MAML2 gene break and/or CTRC1/CRTC3::MAML2 gene fusion. This evidence concerns the gene MAML2 and mucoepidermoid carcinoma.