However, before making an ultimate conclusion that TG7371 is an optimal model to study the role ACE2/ANG 1-7/MAS arm in the pathophysiology of cardio-renal diseases, and before exploration of the possible benefit of activation of this axis in hypertension, HF and CKD, some limitations in the characterization of the model should be indicated. This evidence concerns the gene ACE2 and hydrops fetalis.