Commonly mutated genes in CHIP include DNMT3A, TET2, ASXL1, PPM1D and JAK2. CHIP patients are reportedly at a ~10-fold and ~3-fold higher risk of developing leukemia and cardiovascular conditions, respectively [4–7], although recent reports have questioned the correlation with cardiovascular disease [7]. The gene discussed is DNMT3A; the disease is leukemia.