NOTCH3 and cyclic hematopoiesis: Hence, considering this high prevalence of CADASIL-NOTCH3 variants [19], and our data indicating that: (i) NOTCH3C455R CADASIL mutations allow a selective advantage in HSPCs; and (ii) that the presence of NOTCH3C455R hematopoietic cells provides a non-autonomous selective advantage to DNMT3AR882H clones, it would very relevant to investigate the correlation of CADASIL-NOTCH3 mutations in the general population and CH development.