Six of these mutations occurred in regions conserved in the human genome and associated with malignancy: Bcl11b, Hist1h2ac, Npy2r, Notch3, Ptprr and Top2b. Particularly, NOTCH3 activating mutations constitute oncogenic drivers of various human cancers, including T-cell acute lymphoblastic leukemia (T-ALL) [12–14]. This evidence concerns the gene NOTCH3 and cancer.