Since NOTCH3 signaling plays a role in macrophage activation via NF-κB [37] and aberrant NOTCH signaling contributes to T-ALL growth [14], we transcriptionally profiled PB CD11b+Gr1− myeloid cells (comprising macrophages and monocytes) and mature T-cells to investigate the effects of NOTCH3-C455R expression on these differentiated cell types. The gene discussed is ITGAM; the disease is acute lymphoblastic leukemia.