Importantly, V122I TTR carriers were at a higher adjusted risk of heart failure (HR 3.82, 95% CI 1.80–8.13, P < 0.001), cardiovascular death (HR 2.65, 95% CI 1.14–6.15, P = 0.023), and all-cause mortality (HR 1.95, 95% CI 1.08–3.51, P = 0.026) compared to non-carriers. The gene discussed is TTR; the disease is heart failure.