NDUFS3 and hydrops fetalis: Additionally, an interactome containing both PLEC and NDUFS3 was enriched with HF and was upregulated in the pathways related to “aerobic electron transport chain” in endothelial cells (Fig. 4D) and “acetyl-CoA biosynthetic process from pyruvate” and “energy coupled proton transport” in cardiomyocytes (Supplementary Fig. 11).