APOE and Alzheimer disease: Among the 21 loci with evidence for colocalisation, there were three loci for which a single candidate causal variant explained a large proportion of the association: rs11786896 (mapped in PLEC; colocalised with AD-AF; PP = 0.97; 86% of PP explained by SNP), rs7529220 (mapped in HSPG2; colocalised with AD-AF; PP = 1; 90% of PP explained by SNP) and rs429358 (mapped in APOE; colocalised with AD-CAD; PP = 0.57; 93% of PP explained by SNP).