In this study, the western blot results revealed that SPINK13 downregulated Hes1 levels while causing a decrease in cleaved Notch1 levels in tumor tissues and consequently downregulated the activation of PTEN expression, which in turn inhibited Akt phosphorylation (Fig. 7F), which differs from the results of the data analysis. The gene discussed is AKT1; the disease is neoplasm.