SOST and myocardial infarction: However, random-effects results showed an association between lower levels of sclerostin and decreased levels of apolipoprotein-A (beta = −0.22 [−0.38, −0.07]), and with increased risk of myocardial infarction (OR = 2.67 [1.16, 6.1]; HR = 2.62 [1.17, 5.84]).