S100A8 and inflammatory bowel disease: In addition, compared with the WT_Veh group, the WT_DSS group showed significant up-regulation of myeloid genes, particularly those related to neutrophil development, such as S100a8, S100a9, and Ngp (Fig 5C), consistent with previous studies suggesting serum levels of S100a8 and S100a9 are potential biomarkers for inflammatory bowel disease (43).