TNF and Chronic colitis: When paying attention to the different consequences caused by gene mutation in Tet2 and chronic inflammation by DSS treatment, we noticed that the hematopoietic abnormalities caused by Tet2-LOF mainly involve in abnormal activation of the IFN signaling pathway (44) and TGF-β signaling pathway (Fig 5E and F), whereas that caused by DSS-induced chronic colitis is mainly associated with the activation of the TNF-α (45) (Fig 5G and H).