We show that like cholinergic interneurons, rare PV neurons also lose primary cilia and their ability to carry out Shh signaling; the consequence of PV neuron ciliary loss is a major reduction in GDNF-related Neurturin (NRTN) expression, and a loss of cell numbers, decreasing neuroprotection for vulnerable dopamine neurons, and contributing to Parkinson’s disease. Here, SHH is linked to Parkinson disease.