When hemophilia A was simulated by reducing FVIII to 1% (from 1 nM at 100% to 0.01 nM at 1%, as used in our previous work [26]), concizumab did not elevate thrombin generation above 1 nM within 40 minutes when TF was low (4 fmol/cm2). This evidence concerns the gene TF and hemophilia A.