We analyzed the expression of the IL-21R on leukemic granulocyte-monocyte progenitors (L-GMPs), which represent the LSC population in mixed lineage leukemia (MLL)-AF9 (KMT2A-MLLT3) AML mice, and the level of IL-21 in the BM in a murine AML model.26 This evidence concerns the gene KMT2A and acute myeloid leukemia.