In addition, staining with the mitochondrial probes MitoTracker and TMRM revealed, respectively, that L-GMPs in the BM of Il21−/− AML mice had increased mitochondrial mass, without displaying changes in their mitochondrial membrane potential, which is consistent with LSC dependency on oxidative phosphorylation (OXPHOS) for their metabolism (Figures S3D and S3E). Here, IL21 is linked to acute myeloid leukemia.