4 Ho Ho MY MY Wang Wang CY CY Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy Cells Cells 2021 2021 10 10 8 8 2103 2103 10.3390/cells10082103 10.3390/cells10082103 34440871 34440871. This evidence concerns the gene FNDC5 and heart failure.