Additionally, since evidence suggests that PM2.5 may induce eczema via non-canonical AhR signaling, activation of canonical AhR signaling may balance such immune dysregulation; the AhR agonist tapinarof is currently under investigation for treatment of eczema and may be of particular utility for those exposed to elevated PM2.5 levels [39, 40]. Here, AHR is linked to Eczematoid dermatitis.