BIRC5 and neoplasm: EMT is orchestrated by complex signaling networks involving transforming growth factor‐β (TGF‐β) and hypoxia‐inducible factor 1‐alpha (HIF‐1α), both of which regulate survivin expression[30, 31] and contribute to tumor aggressiveness under hypoxic conditions.[32, 33, 34] TGF‐β promotes EMT by downregulating epithelial markers and upregulating mesenchymal markers, facilitating tumor cell invasion and metastasis.