In all of the mentioned significant variables, the percentage of developing cognitive impairments at V3 was higher in participants with positive results at V1 (dysosmia: yes 22.3%; no 7.1%; ApoE4 risk alleles: yes 17.8%; no 7.9%; diabetes mellitus: yes 22.9%; no 8.5%; relatives notice memory impairments: yes 17.1%; no 8.5%; lifetime panic attacks: yes 15.8%; no 9.0%). The gene discussed is APOE; the disease is diabetes mellitus.