The pathogenesis of AD is multifactorial in origin, and neural alterations are present at nearly every cellular level (Duchesne et al. 2024), comprising disturbance in production, accumulation, or removal of ß-Amyloid and its different precursors (Granzotto and Sensi 2024), regulation in Tau (Roda et al. 2022) and many other factors. The gene discussed is MAPT; the disease is Alzheimer disease.