Consistent with previous findings, proteins associated with the matrisome (ie, module 42 of the brain consensus network21) exhibited the highest positive correlations with APP. MDK had the highest correlation (bicor = 0.88, p = 0), followed by SMOC1, NTN1, CTHRC1, and SFRP1, all known to colocalize with amyloid plaques and be enriched in amyloid plaque proteomes.54, 55, 56. The gene discussed is CTHRC1; the disease is amyloidosis.