APP and Alzheimer disease: Consistent with the existing literature,21, 41, 42 top‐ranking proteins associated with AD, including APP, which has been shown to correlate with Aβ plaque burden in the brain,21 as well as other amyloid‐associated matrisome proteins, CTHRC1, SMOC1, MDK, and NTN1, exhibited significantly higher levels among AD cases43, 44 (Figure 3E andS2E).