Consistent with previous proteomic analyses of AD brain tissue, there was a significant increase in key proteins associated with AD pathology, such as matrisome‐associated proteins (eg, MDK, SMOC1, APOE, APP), as well as proteins involved in neuroinflammation (eg, GFAP, ICAM1) and synaptic function (eg, VGF, NPTX2) in both African Americans and White individuals with AD compared to controls in the same racial group. Here, SMOC1 is linked to Alzheimer disease.