Integrin αvβ5 then activates the SRC proto‐oncogene, nonreceptor tyrosine kinase (Src) signaling pathway and the signal transducer and activator of transcription 3 (STAT3) pathway, which promotes tumor growth driven by glioblastoma (GBM) stem cells.[18] In ovarian cancer, periostin (POSTN) interacts with integrin αvβ3 and integrin αvβ5 and regulates macrophage polarization through nuclear factor kappa B (NF‐kB).[19] However, the role of ITGβ8 in LUAD cells and TAMs has not yet been elucidated. This evidence concerns the gene STAT3 and neoplasm.