The PI3K/AKT signaling pathway is a critical pathway that regulates tumor proliferation and metastasis.[45] The activation of AKT can directly or indirectly activate pro‐EMT transcription factors, stimulate the EMT process, and induce prometastatic molecules, leading to tumor metastasis.[46] Notably, the overexpression of ITGβ8 activated the phosphorylation of key PI3K/AKT proteins in LUAD cells, and treatment with LY294002 reversed the increase in CCL5 secretion observed in ITGβ8‐overexpressing LUAD cells. Here, ITGB8 is linked to neoplasm.