In NSCLC, circ‐0017956 promotes the proliferation and metastasis of NSCLC cells by regulating the miR‐515‐5p/ITGβ8 axis.[34] In bladder carcinoma, ITGβ8 regulates the phosphorylation of Y box binding protein 1 (YBX1) and activates BCL2 apoptosis regulator (BCL2), which leads to drug resistance.[35] However, research on the role of ITGβ8 in the crosstalk between tumor cells and the TME in LUAD is still limited. This evidence concerns the gene BCL2 and non-small cell lung carcinoma.