When mediation analyses were performed in the set of participants with DS with full data (N = 130), plasma GFAP mediated 15.3% of the relationship between amyloid PET and tau PET (p = 0.038; Table S8), and 42.1% of the relationship between amyloid PET and plasma pTau‐217 (p < 0.001; Table S10). This evidence concerns the gene MAPT and Dravet syndrome.