Evidence summary and rationale: The panel concluded that there was insufficient evidence to support transfusion with RBCs prophylactically matched for Fya, Fyb, Jka, Jkb, S, and s antigens (in addition to ABO, RhD, RhCcEe, and K) to reduce the risk of alloimmunisation or delayed HTRs in patients with SCD. This evidence concerns the gene RHD and Schnyder corneal dystrophy.