Evidence summary and rationale: The panel concluded that there was insufficient evidence to support transfusion with RBCs prophylactically matched for Fya, Fyb, Jka, Jkb, S, and s antigens (in addition to ABO, RhD, RhCcEe, and K) to reduce the risk of alloimmunisation or delayed HTRs in patients with SCD. The gene discussed is ABO; the disease is Schnyder corneal dystrophy.