Fumagalli et al., 2020, have recently shown that the generation of Lgr5 positive cells from the metastasized Lgr5 negative cancer cells is necessary for their outgrowth using in vivo time-lapse imaging and organoid culture of metastatic cancer cells that escaped from the primary colon cancer tissues (Fumagalli et al., 2020). Here, LGR5 is linked to malignant colon neoplasm.