Although infection of anti-IFNAR1-treated wild-type (WT) mice or Xcr1-Cre Ifnar1fl/fl mice resulted in higher viral burden in the foot and DLN, the greater antigen load did not fully explain the enhanced RRV-specific CD8+ T response since the improvement in effector CD8+ T cells was largely retained in anti-IFNAR1-treated Wdfy4−/− mice lacking antigen cross-presentation and was not observed in WT mice infected with 1,000-fold higher inoculating doses of RRV. This evidence concerns the gene CD8A and infection.