Lastly, the susceptibility to VACV and TNX-801 infection of three new immunocompromised murine models (C56BL/6 Ifnar−/−, C56BL/6 Ifngr−/−, and C56BL/6 Ifnar−/−/Ifngr−/−) was investigated. The gene discussed is IFNAR1; the disease is infection.