In the brain, CXCR3-expressing cells have been implicated in Alzheimer’s disease and other age-dependent cognitive dysfunctions (Jorfi et al., 2023; Schroer et al., 2023), multiple sclerosis (Bogers et al., 2023), epilepsy (Liang et al., 2023), and stroke (Cai et al., 2022). Here, CXCR3 is linked to early-onset autosomal dominant Alzheimer disease.