Among the top enriched canonical pathways, we identified Intra-Golgi and Retrograde Golgi-to-ER Traffic, as well as DNA Methylation and Transcriptional Repression signaling for breast cancer; Cytosolic Iron-Sulfur Cluster Assembly and Glycerophospholipid Biosynthesis for prostate cancer; and cancer immune-related pathways such as Antigen Presentation, Interferon Gamma Signaling and PD-1/PD-L1 Cancer Immunotherapy for lung cancer (Supplementary Data 19). The gene discussed is CD274; the disease is lung carcinoma.