Moreover, multiple GPX4-independent antioxidant enzymes, such as apoptosis-inducing factor mitochondria-associated 2 (AIFM2, also known as FSP1)[30,31] and dihydroorotate dehydrogenase (DHODH)[32], inhibit ferroptosis in cancer cells with low GPX4 expression. This evidence concerns the gene AIFM2 and cancer.