Indeed, RNAi-mediated knockdown of SQSTM1 increases KEAP1 protein levels, enhances the interaction between KEAP1 and NFE2L2, and promotes the degradation of NFE2L2 in HCC cells in response to ferroptosis inducers, such as erastin and sorafenib[6]. Here, NFE2L2 is linked to hepatocellular carcinoma.