The expression of TWIK-1 is increased in the heart of patients with Brugada syndrome, which may suggest that TWIK-1 is involved in the occurrence and development of repolarization disorder in Brugada syndrome by promoting potassium efflux, shortening APD, and leading to idiopathic ventricular fibrillation. This evidence concerns the gene KCNK1 and paroxysmal familial ventricular fibrillation.