KCNK1 and cardiac arrhythmia: In addition, clinical studies have found that the expression of TWIK-1 is relatively upregulated in patients with Brugada syndrome, suggesting that TWIK-1 may play a specific role in the arrhythmia of Brugada syndrome (such as idiopathic ventricular fibrillation) (Nathalie et al., 2009).