Circadian misalignment is also linked to cancer progression, especially among shift workers who experience chronic disruptions. The IARC has classified shift work that disrupts circadian rhythms as potentially carcinogenic (Group 2A) [16]. This classification serves as a stark reminder of the serious health consequences associated with our increasingly 24/7 lifestyle. The long-term risks, including an elevated risk of cancer, are becoming increasingly clear as we continue to push the boundaries of natural circadian rhythms with artificial lighting and around-the-clock activities. The gene discussed is CLOCK; the disease is cancer.