The circadian rhythm regulates key cardiovascular functions, including the adrenal medullary system, the renin-angiotensin system, and sympathetic activity, which in turn influence catecholamine secretion and aldosterone biosynthesis. Disruption of the circadian rhythm can negatively impact these processes and alter fuel metabolism in the heart. Moreover, professions that involve night shifts, such as airline crew members, are at an increased risk of stroke, heart attacks, and other coronary events [16,17]. The gene discussed is REN; the disease is stroke disorder.