It inhibited obesity-induced IR by ameliorating inflammatory events in adipose tissue through the downregulation of the nuclear factor kappa-B kinase subunit beta (IKKβ)/nuclear factor kappa B (NF-κB) and c-Jun-N-terminal kinase (JNK) signaling pathway [24]. The gene discussed is IKBKB; the disease is obesity due to melanocortin 4 receptor deficiency.